Misdeed of the need: towards computational accounts of transition to addiction.

Mehdi Keramati, Serge H Ahmed, Boris S Gutkin
Current Opinion in Neurobiology. 2017-10-01; 46: 142-153
DOI: 10.1016/j.conb.2017.08.014

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1. Curr Opin Neurobiol. 2017 Oct;46:142-153. doi: 10.1016/j.conb.2017.08.014. Epub
2017 Sep 9.

Misdeed of the need: towards computational accounts of transition to addiction.

Keramati M(1), Ahmed SH(2), Gutkin BS(3).

Author information:
(1)Gatsby Computational Neuroscience Unit, University College London, London, UK.
(2)Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
146 rue Léo-Saignat, F-33000 Bordeaux, France; CNRS, Institut des Maladies
Neurodégénératives, UMR 5293, 146 rue Léo-Saignat, F-33000 Bordeaux, France.
(3)Group for Neural Theory, Laboratoire de Neurosciences Cognitives, ENS, INSERM,
PSL Research University, 75005 Paris, France; Center for Cognition and Decision
Making, Department of Psychology, NRU Higher School of Economics, Moscow, Russia.
Electronic address: .

Drug addiction is a complex behavioral and neurobiological disorder which, in an
emergent brain-circuit view, reflects a loss of prefrontal top-down control over
subcortical circuits governing drug-seeking and drug-taking. We first review
previous computational accounts of addiction, focusing on cocaine addiction and
on prevalent dopamine-based positive-reinforcement and negative-reinforcement
computational models. Then, we discuss a recent computational proposal that the
progression to addiction is unlikely to result from a complete withdrawal of the
goal-oriented decision system in favor the habitual one. Rather, the transition
to addiction would arise from a drug-induced alteration in the structure of
organismal needs which reorganizes the goal structure, ultimately favoring
predominance of drug-oriented goals. Finally, we outline unmet challenges for
future computational research on addiction.

Copyright © 2017 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.conb.2017.08.014
PMID: 28892737 [Indexed for MEDLINE]


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