miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling.

Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine, Alexandre Favereaux
Nat Neurosci. 2014-07-13; 17(8): 1040-1042
DOI: 10.1038/nn.3762

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1. Nat Neurosci. 2014 Aug;17(8):1040-2. doi: 10.1038/nn.3762. Epub 2014 Jul 13.

miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during
homeostatic scaling.

Letellier M(1), Elramah S(1), Mondin M(1), Soula A(2), Penn A(2), Choquet D(2),
Landry M(2), Thoumine O(1), Favereaux A(1).

Author information:
(1)1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR
5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience,
UMR 5297, Bordeaux, France. [3].
(2)1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR
5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience,
UMR 5297, Bordeaux, France.

Erratum in
Nat Neurosci. 2014 Dec;17(12):1841.

We investigated whether microRNAs could regulate AMPA receptor expression during
activity blockade. miR-92a strongly repressed the translation of GluA1 receptors
by binding the 3′ untranslated region of rat GluA1 (also known as Gria1) mRNA and
was downregulated in rat hippocampal neurons after treatment with tetrodotoxin
and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked
homeostatic scaling, indicating that miR-92a regulates the translation and
synaptic incorporation of new GluA1-containing AMPA receptors.

 


Auteurs Bordeaux Neurocampus