Microglia in neuronal plasticity: Influence of stress

Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé
Neuropharmacology. 2015-09-01; 96: 19-28
DOI: 10.1016/j.neuropharm.2014.12.034

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1. Neuropharmacology. 2015 Sep;96(Pt A):19-28. doi:
10.1016/j.neuropharm.2014.12.034. Epub 2015 Jan 9.

Microglia in neuronal plasticity: Influence of stress.

Delpech JC(1), Madore C(1), Nadjar A(1), Joffre C(1), Wohleb ES(2), Layé S(3).

Author information:
(1)Nutrition et Neurobiologie Intégrée, INRA 1286, 33077 Bordeaux Cedex, France;
Nutrition et Neurobiologie Intégrée, University of Bordeaux, Bordeaux 33077,
France.
(2)Department of Psychiatry, Yale University School of Medicine, New Haven, CT
06519, USA.
(3)Nutrition et Neurobiologie Intégrée, INRA 1286, 33077 Bordeaux Cedex, France;
Nutrition et Neurobiologie Intégrée, University of Bordeaux, Bordeaux 33077,
France. Electronic address: .

The central nervous system (CNS) has previously been regarded as an
immune-privileged site with the absence of immune cell responses but this dogma
was not entirely true. Microglia are the brain innate immune cells and recent
findings indicate that they participate both in CNS disease and infection as well
as facilitate normal CNS function. Microglia are highly plastic and play integral
roles in sculpting the structure of the CNS, refining neuronal circuitry and
connectivity, and contribute actively to neuronal plasticity in the healthy
brain. Interestingly, psychological stress can perturb the function of microglia
in association with an impaired neuronal plasticity and the development of
emotional behavior alterations. As a result it seemed important to describe in
this review some findings indicating that the stress-induced microglia
dysfunction may underlie neuroplasticity deficits associated to many mood
disorders. This article is part of a Special Issue entitled ‘Neuroimmunology and
Synaptic Function’.

Copyright © 2015 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neuropharm.2014.12.034
PMID: 25582288 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus