Metabotropic receptors for glutamate and GABA in pain
Brain Research Reviews. 2009-04-01; 60(1): 43-56
DOI: 10.1016/j.brainresrev.2008.12.007
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1. Brain Res Rev. 2009 Apr;60(1):43-56. doi: 10.1016/j.brainresrev.2008.12.007. Epub
2008 Dec 25.
Metabotropic receptors for glutamate and GABA in pain.
Goudet C(1), Magnaghi V, Landry M, Nagy F, Gereau RW 4th, Pin JP.
Author information:
(1)Univ Montpellier I and II, CNRS UMR5203, Institut de Génomique Fonctionnelle,
Montpellier Cedex 5, F-34094, France.
Glutamate and gamma-amino butyric acid (GABA) are respectively two major
excitatory and inhibitory neurotransmitters of the adult mammalian central
nervous system. These neurotransmitters exert their action through two types of
receptors: ionotropic and metabotropic receptors. While ionotropic receptors are
ligand gated ion channels involved in fast synaptic transmission, metabotropic
receptors belong to the superfamily of G-protein coupled receptors (GPCRs) and
are responsible for the neuromodulatory effect of glutamate and GABA.
Metabotropic glutamate receptors (mGluRs) and metabotropic GABA receptors
(GABA-B) are present at different levels of the pain neuraxis where they regulate
nociceptive transmission and pain. The present review will focus on the role of
these receptors in the modulation of pain perception.
DOI: 10.1016/j.brainresrev.2008.12.007
PMID: 19146876 [Indexed for MEDLINE]