Memory
Cell. Mol. Life Sci.. 2006-04-05; 63(9): 999-1008
DOI: 10.1007/s00018-006-6025-7
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Memories become stabilized through a time-dependent process that requires gene
expression and is commonly known as consolidation. During this time, memories are
labile and can be disrupted by a number of interfering events, including
electroconvulsive shock, trauma and other learning or the transient effect of
drugs such as protein synthesis inhibitors. Once consolidated, memories are
insensitive to these disruptions. However, they can again become fragile if
recalled or reactivated. Reactivation creates another time-dependent process,
known as reconsolidation, during which the memory is restabilized. Here we
discuss some of the questions currently debated in the field of memory
consolidation and reconsolidation, the molecular and anatomical requirements for
both processes and, finally, their functional relationship.