Mediterranean diet and preserved brain structural connectivity in older subjects.
Alzheimer's & Dementia. 2015-07-16; 11(9): 1023-1031
DOI: 10.1016/j.jalz.2015.06.1888
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1. Alzheimers Dement. 2015 Sep;11(9):1023-31. doi: 10.1016/j.jalz.2015.06.1888. Epub
2015 Jul 17.
Mediterranean diet and preserved brain structural connectivity in older subjects.
Pelletier A(1), Barul C(1), Féart C(1), Helmer C(1), Bernard C(2), Periot O(3),
Dilharreguy B(2), Dartigues JF(1), Allard M(4), Barberger-Gateau P(1), Catheline
G(5), Samieri C(6).
Author information:
(1)Univ. Bordeaux, ISPED, Centre INSERM U897, F-33076 Bordeaux, France; INSERM,
ISPED, Centre INSERM U897, F-33076 Bordeaux, France.
(2)Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR
5287, F-33076 Bordeaux, France.
(3)Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR
5287, F-33076 Bordeaux, France; CHU de Bordeaux, F-33076 Bordeaux, France.
(4)Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR
5287, F-33076 Bordeaux, France; CHU de Bordeaux, F-33076 Bordeaux, France; EPHE,
Laboratoire Neurobiologie Intégrative et Adaptative, F-33076 Bordeaux, France.
(5)Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR
5287, F-33076 Bordeaux, France; EPHE, Laboratoire Neurobiologie Intégrative et
Adaptative, F-33076 Bordeaux, France.
(6)Univ. Bordeaux, ISPED, Centre INSERM U897, F-33076 Bordeaux, France; INSERM,
ISPED, Centre INSERM U897, F-33076 Bordeaux, France. Electronic address:
.
INTRODUCTION: The Mediterranean diet (MeDi) has been related to a lower risk of
Alzheimer’s disease; yet, the underlying mechanisms are unknown. We hypothesized
that protection against neurodegeneration would translate into higher gray matter
volumes, whereas a specific association with preserved white matter
microstructure would suggest alternative mechanisms (e.g., vascular pathways).
METHODS: We included 146 participants from the Bordeaux Three-City study
nondemented when they completed a dietary questionnaire and who underwent a 3-T
magnetic resonance imaging at an average of 9 years later, including diffusion
tensor imaging.
RESULTS: In multivariate voxel-by-voxel analyses, adherence to the MeDi was
significantly associated with preserved white matter microstructure in extensive
areas, a gain in structural connectivity that was related to strong cognitive
benefits. In contrast, we found no relation with gray matter volumes.
DISCUSSION: The MeDi appears to benefit brain health through preservation of
structural connectivity. Potential mediation by a favorable impact on brain
vasculature deserves further research.
Copyright © 2015 The Alzheimer’s Association. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.jalz.2015.06.1888
PMID: 26190494 [Indexed for MEDLINE]