Meal scheduling corrects obesogenic diet induced-uncoupling of cortico-hippocampal activities supporting memory
eBioMedicine. 2025-07-01; 117: 105783
DOI: 10.1016/j.ebiom.2025.105783
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https://www.bordeaux-neurocampus.fr/12115
1. EBioMedicine. 2025 Jul;117:105783. doi: 10.1016/j.ebiom.2025.105783. Epub 2025
Jun 16.
Meal scheduling corrects obesogenic diet induced-uncoupling of
cortico-hippocampal activities supporting memory.
Chakraborty P(1), Dromard Y(2), André EM(3), Dedin M(2), Arango-Lievano M(2),
Raner A(4), Besnard A(2), Silva TS(2), Helbling JC(4), Ferreira G(4), Challet
E(5), Moisan MP(6), Jeanneteau F(7).
Author information:
(1)Institut de Génomique Fonctionnelle, University of Montpellier, INSERM, CNRS,
141 rue de la Cardonille, 34094, Montpellier, France; Department of Genetic
Engineering, School of Bioengineering, Faculty of Engineering and Technology,
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 60203,
India.
(2)Institut de Génomique Fonctionnelle, University of Montpellier, INSERM, CNRS,
141 rue de la Cardonille, 34094, Montpellier, France.
(3)Institut de Génomique Fonctionnelle, University of Montpellier, INSERM, CNRS,
141 rue de la Cardonille, 34094, Montpellier, France; Département de Maieutique,
University of Montpellier, 641 Avenue du Doyen Gaston Giraud, 34070, France.
(4)Univ. Bordeaux, INRAE, INP Bordeaux, Nutrition et Neurobiologie intégrée,
NutriNeurO, 146 Rue Léo Saignat, 33076, Bordeaux, France.
(5)Institut des Neuroscience Cellulaires et intégratives, University of
Strasbourg, CNRS, 8 All. du Général Rouvillois, 67000, Strasbourg, France.
(6)Univ. Bordeaux, INRAE, INP Bordeaux, Nutrition et Neurobiologie intégrée,
NutriNeurO, 146 Rue Léo Saignat, 33076, Bordeaux, France. Electronic address:
.
(7)Institut de Génomique Fonctionnelle, University of Montpellier, INSERM, CNRS,
141 rue de la Cardonille, 34094, Montpellier, France. Electronic address:
.
BACKGROUND: Highly caloric food consumed around the clock perturbs the
metabolism and cognitive functioning. We hypothesised that obesogenic food could
alter neuronal representations of memory depending on the feeding-fasting cycle.
METHODS: We tracked memory performance, dendritic spine dynamics and neuronal
representations of memory in C57Bl6J mice fed obesogenic food ad libitum from
peri-adolescence. We aimed to correct energy rich diet-induced plasticity
deficits and cognitive impairment with time-restricted feeding in males and
females. We further used chemogenetics, pharmacology and knock-in mice to
investigate functional correlates underlying diet-induced neurocognitive
impairments.
FINDINGS: We found that changes in the feeding-fasting cycle reverted the
effects of ad libitum obesogenic food on memory impairment in both sexes (n =
55, p = 0.003). Concurrently, it also corrected the increased dendritic spine
maintenance and neuroactivity in hippocampus and the decreased spine maintenance
and activity in parietal cortex (n = 48, p < 0.005). Bi-directional effects in
cortex and hippocampus mediated by glucocorticoid signalling are causal to
behavioural changes (n = 91, p = 0.0008), and scaling hippocampal with cortical
activities restored memory in mice fed obesogenic food (n = 44, p = 0.02).
INTERPRETATION: These results indicate that meal scheduling is a promising
approach to confront glucocorticoid signalling bias and memory deficits caused
by obesogenic food.
FUNDING: Agence Nationale de la Recherche (ANR-21-CE14-0086), Fondation pour la
Recherche sur le Cerveau (FRC).
Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.ebiom.2025.105783
PMCID: PMC12209983
PMID: 40527010 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests EC, FJ, MPM received
grant from ANR. GF and FJ received funding from FRC. All other authors declare
no conflict of interest.