Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects.
Brain, Behavior, and Immunity. 2016-11-01; 58: 63-68
DOI: 10.1016/j.bbi.2016.05.013
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1. Brain Behav Immun. 2016 Nov;58:63-68. doi: 10.1016/j.bbi.2016.05.013. Epub 2016
May 17.
Low-grade inflammation is a major contributor of impaired attentional set
shifting in obese subjects.
Lasselin J(1), Magne E(2), Beau C(2), Aubert A(3), Dexpert S(3), Carrez J(3),
Layé S(3), Forestier D(2), Ledaguenel P(2), Capuron L(4).
Author information:
(1)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; Univ Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, F-33076 Bordeaux, France; Institute of Medical Psychology
and Behavioral Immunobiology, Universitätsklinikum Essen, 45 122 Essen, Germany;
Department of Clinical Neuroscience, Division for Psychology, Karolinska
Institutet, 171 65 Solna, Sweden; Stress Research Institute, Stockholm
University, 106 91 Stockholm, Sweden.
(2)Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, F-33000
Bordeaux, France; Clinique Jean Villar, F-33520 Bruges, France.
(3)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; Univ Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, F-33076 Bordeaux, France.
(4)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; Univ Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, F-33076 Bordeaux, France. Electronic address:
.
Impairment in cognitive flexibility and set shifting abilities has been described
in obesity. This alteration is critical as it can interfere with obesity
management strategies. Recent evidences suggest that chronic low-grade
inflammation may be involved in cognitive deficits associated with obesity, but
the potential involvement in reduced flexibility remains unknown. The objective
of this study was to assess the contribution of low-grade inflammation,
determined by circulating levels of high-sensitivity C-reactive protein (hsCRP),
in reduced cognitive flexibility and shifting abilities of obese subjects
relatively to a group of non-obese participants. Performance in the
intra/extra-dimensional set shift (IED) test, extracted from the CANTAB, was
assessed in 66 obese subjects and 20 non-obese participants. Obese subjects with
concentrations of hsCRP above 5mg/L exhibited reduced performance on the IED test
in comparison to obese subjects with lower levels of hsCRP and non-obese
participants. This difference was particularly manifest in the number of errors
made during the extra-dimensional shift (EDS errors). In contrast, performance
before the extra-dimensional shift was spared. Linear regression analyses
revealed that the association between obesity and IED alterations was significant
only when the condition hsCRP >5mg/L was entered in the model. These findings are
important as they indicate that, rather than obesity itself, low-grade
inflammation represents a major contributor of IED performance in obese subjects.
Copyright © 2016 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbi.2016.05.013
PMID: 27223095 [Indexed for MEDLINE]