Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume.

Owen Carmichael, Jing Xie, Evan Fletcher, Baljeet Singh, Charles DeCarli
Neurobiology of Aging. 2012-06-01; 33(6): 1124.e31-1124.e41
DOI: 10.1016/j.neurobiolaging.2011.08.016

PubMed
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Carmichael O, Xie J, Fletcher E, Singh B, DeCarli C; Alzheimer’s Disease Neuroimaging Initiative.

Collaborators: A S, Abdi H, Abdul Hadi N, Abdulkadir A, Abdullah A, Achuthan A,
Adluru N, Aggarwal N, Aghajanian J, Agyemang A, Ahdidan J, Ahmad D, Ahmed S,
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Hippocampal injury in the Alzheimer’s disease (AD) pathological process is
region-specific and magnetic resonance imaging (MRI)-based measures of localized
hippocampus (HP) atrophy are known to detect region-specific changes associated
with clinical AD, but it is unclear whether these measures provide information
that is independent of that already provided by measures of total HP volume.
Therefore, this study assessed the strength of association between localized HP
atrophy measures and AD-related measures including cerebrospinal fluid (CSF)
amyloid beta and tau concentrations, and cognitive performance, in statistical
models that also included total HP volume as a covariate. A computational
technique termed localized components analysis (LoCA) was used to identify 7
independent patterns of HP atrophy among 390 semiautomatically delineated HP from
baseline magnetic resonance imaging of participants in the Alzheimer’s Disease
Neuroimaging Initiative (ADNI). Among cognitively normal participants, multiple
measures of localized HP atrophy were significantly associated with CSF amyloid
concentration, while total HP volume was not. In addition, among all
participants, localized HP atrophy measures and total HP volume were both
independently and additively associated with CSF tau concentration, performance
on numerous neuropsychological tests, and discrimination between normal, mild
cognitive impairment (MCI), and AD clinical diagnostic groups. Together, these
results suggest that regional measures of hippocampal atrophy provided by
localized components analysis may be more sensitive than total HP volume to the
effects of AD pathology burden among cognitively normal individuals and may
provide information about HP regions whose deficits may have especially profound
cognitive consequences throughout the AD clinical course.

Copyright © 2012 Elsevier Inc. All rights reserved.

Auteurs Bordeaux Neurocampus