Local generation of multineuronal spike sequences in the hippocampal CA1 region.
Proc Natl Acad Sci USA. 2015-08-03; 112(33): 10521-10526
DOI: 10.1073/pnas.1508785112
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1. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10521-6. doi:
10.1073/pnas.1508785112. Epub 2015 Aug 3.
Local generation of multineuronal spike sequences in the hippocampal CA1 region.
Stark E(1), Roux L(2), Eichler R(2), Buzsáki G(3).
Author information:
(1)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016; Department of Physiology and Pharmacology, Sackler Faculty of Medicine,
Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel
Aviv University, 69978 Tel Aviv, Israel
.
(2)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016;
(3)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016; .
Sequential activity of multineuronal spiking can be observed during theta and
high-frequency ripple oscillations in the hippocampal CA1 region and is linked to
experience, but the mechanisms underlying such sequences are unknown. We compared
multineuronal spiking during theta oscillations, spontaneous ripples, and focal
optically induced high-frequency oscillations (« synthetic » ripples) in freely
moving mice. Firing rates and rate modulations of individual neurons, and
multineuronal sequences of pyramidal cell and interneuron spiking, were
correlated during theta oscillations, spontaneous ripples, and synthetic ripples.
Interneuron spiking was crucial for sequence consistency. These results suggest
that participation of single neurons and their sequential order in population
events are not strictly determined by extrinsic inputs but also influenced by
local-circuit properties, including synapses between local neurons and
single-neuron biophysics.
DOI: 10.1073/pnas.1508785112
PMCID: PMC4547251
PMID: 26240336 [Indexed for MEDLINE]