Local facilitation of hippocampal metabotropic glutamate receptor-dependent long-term depression by corticosterone and dexamethasone
Psychoneuroendocrinology. 2008-06-01; 33(5): 686-691
DOI: 10.1016/j.psyneuen.2007.12.013
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1. Psychoneuroendocrinology. 2008 Jun;33(5):686-91. doi:
10.1016/j.psyneuen.2007.12.013. Epub 2008 Mar 5.
Local facilitation of hippocampal metabotropic glutamate receptor-dependent
long-term depression by corticosterone and dexamethasone.
Chaouloff F(1), Hémar A, Manzoni O.
Author information:
(1)CNRS UMR 5091 Physiologie Cellulaire de la Synapse, Institut de Neurosciences
F. Magendie, Bordeaux, France.
Long-term potentiation and long-term depression (LTD) of synaptic efficacy, two
major forms of synaptic plasticity, are believed to underlie learning processes
and memory storage. We have recently shown that acute stress, through
corticosterone release and stimulation of glucocorticoid receptors (GRs),
facilitates the LTD elicited by the group 1 metabotropic glutamate receptor
(mGluR) agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) in hippocampal CA1
neurons. However, it is unknown whether sustained corticosterone release, per se,
is also able to facilitate DHPG-elicited LTD in control (i.e. unstressed)
conditions, and if so, whether it acts on local (i.e. hippocampal) or distant
GRs. Here, we show that a brief application of 100 nM corticosterone to rat
hippocampal slices lowers the threshold for DHPG-elicited LTD, an effect mimicked
by the local application of the GR agonist dexamethasone. These results show that
high corticosterone release facilitates hippocampal CA1 mGluR-dependent LTD, and
does so through local GRs.
DOI: 10.1016/j.psyneuen.2007.12.013
PMID: 18321654 [Indexed for MEDLINE]