LINGO1 polymorphisms are associated with essential tremor in Europeans.

Sandra Thier, Delia Lorenz, Michael Nothnagel, Giovanni Stevanin, Alexandra Dürr, Almut Nebel, Stefan Schreiber, Gregor Kuhlenbäumer, Günther Deuschl, Stephan Klebe
Mov. Disord.. 2010-03-22; 25(6): 717-723
DOI: 10.1002/mds.22887

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1. Mov Disord. 2010 Apr 30;25(6):717-23. doi: 10.1002/mds.22887.

LINGO1 polymorphisms are associated with essential tremor in Europeans.

Thier S(1), Lorenz D, Nothnagel M, Stevanin G, Dürr A, Nebel A, Schreiber S,
Kuhlenbäumer G, Deuschl G, Klebe S.

Author information:
(1)Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel,
Kiel, Germany.

Essential tremor (ET) is one of the most common movement disorders. Former
association studies focussing on candidate genes in ET found a number of risk
variants but most of them were not replicated. Recently, a genome-wide
association study revealed two intronic sequence variants in the LINGO1 gene
associated with ET. Here, we have confirmed association between sequence variants
in the LINGO1 gene and the ET phenotype in independent German and French ET
samples. The odds ratios for the identified intronic markers rs8030859 (P =
1.0×10(-4)), rs9652490 (P = 9.1×10(-4)), and rs11856808 (P = 3.6×10(-2)) were
1.72 (CI 1.31-2.26), 1.61 (CI 1.21-2.14), and 1.30 (CI 1.02-1.66), respectively,
in our German sample. LINGO1 is an interesting candidate gene because it plays a
key role in central nervous system biology, is selectively expressed in the
nervous system, and is an inhibitor of oligodendrocyte differentiation and
neuronal myelination. Our study gives further evidence that LINGO1 acts as a
susceptibility gene for ET.

2010 Movement Disorder Society

DOI: 10.1002/mds.22887
PMID: 20310002 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus