Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study
Annals of Neurology. 2022-07-12; 92(3): 411-417
DOI: 10.1002/ana.26434
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Prange S(1)(2)(3), Lin Z(4)(5)(6), Nourredine M(7), Danaila T(1)(2), Laurencin C(1)(2), Lagha-Boukbiza O(8)(9), Anheim M(8)(9)(10), Klinger H(2), Longato N(8), Phillipps C(8), Voirin J(11), Polo G(4), Simon E(4), Mertens P(4), Rolland AS(12), Devos D(12), Metereau E(1)(2), Tranchant C(8)(9)(10), Thobois S(1)(2)(13); Predistim study group.
Collaborators: Moreau C, Defebvre L, Carriere N, Grolez G, Baille G, Kreisler,
Pruvo JP, Leclerc, Lopes R, Viard R, Kuchcinski G, Dumont J, Dujardin K,
Delliaux M, Brion M, Touzet G, Reyns N, Delval A, Santraine V, Pleuvret M,
Dautrevaux N, Laugeais V, Coeffet M, Ouk T, Potey C, Leclercq C, Gers E, Corvol
JC, Vidailhet M, Hainque E, Welter ML, Lacomblez L, Grabli D, Roze E, Worbe Y,
Delorme C, You H, Ihle J, Guimeraes-Costa R, Cormier-Dequaire F, Méneret A,
Hartmann A, Mariani LL, Lehericy S, Czernecki V, Pineau F, Bozon F, Huiban C,
Benchetrit E, Karachi C, Navarro S, Cornu P, Welaratne A, Dongmo-Kenfack C,
Mantisi L, Jarry N, Aix S, Lefort C, Rouaud T, Damier P, Derkinderen P, Corbille
AG, Calvier-Auffray E, Rocher ML, Deruet MA, Sylvie R, Vincent R, Séverine LD,
Marques A, Debilly B, Durif F, Derost P, Beal C, Chassain C, Delaby L, Vidal T,
Lemaire JJ, Rieu I, Durand E, Eusebio A, Azulay JP, Witjas T, Fluchère F,
Grimaldi S, Girard N, Benchetrit E, Delfini M, Carron R, Regis J, Spatola G,
Magnaudet C, Solène A, Isabelle B, Olivier C, Houeto JL, Remy G, Anne F,
Manssouri A, Sophie B, Philippe R, Philippe C, Philippe P, Benoit B, Emilie R,
Annie G, Sophie D, Leh F, Bonnet A, Vérin M, Ferré JC, Houvenaghel JF, Haegelen
C, Kestens F, Ory S, Burbaud P, Damon-Perriere N, Meissner W, Tison F, Bannier
S, Krim E, Guehl D, Molinier-Blossier S, Ollivier M, Lacoste M, Auzou N, Bonnet
M, Cuny E, Engelhardt J, Branchard O, Huet C, Blanchard J, Olivier R, Courbon
CB, Magne FO, Moreau MS, Arbus C, Bonneville F, Lotterie JA, Sarrail M, Chaynes
P, Caire F, Harroch E, Maltete D, Lefaucheur R, Fetter D, Magne N, Bioux S,
Loubeyre M, Bliaux E, Pouliquen D, Derrey S, Vernon L, Ziegler F, Anheim M,
Lagha-Boukbiza O, Tranchant C, Gebus O, Montaut S, Kremer S, Longato N, Phillips
C, Voirin J, des Neiges Santin M, Chaussemy D, Mengin A, Girodana C, Marsé C,
Mondot L, Giordana B, Kardous R, Bailet B, Joly H, Fontaine D, Leplus A,
Faustini A, Ferrier V, Krystkowiak P, Tir M, Constans JM, Wannepain S, Seling A,
Lefranc M, Blin S, Schuler B, Thobois S, Danaila T, Laurencin C, Berthezene Y,
Ameli R, Klinger H, Polo G, Mertens P, Nunes A, Metereau E, Hopes L, Frismand S,
Schmitt E, Meyer M, Dillier C, Colnat S, Chatelain A, Brandel JP, Hubsch C,
Karsenti P, Lebouteux M, Ziegler M, Delmaire C, Savatowky J, Vrillac J, Nakache
C, D’Hardemare V, Belamri L, Bourdain F, Afanassiev V, Graveleau P, Bonnet C,
Mesnage V, Junior JCL, Decrocq C, Boulin A, Dupuy E, Barre I, Gardel B, Jarraya
B, Lopez D, Fruit C, Ziz C, Gay D, Bonicel R, El Mountassir F, Fischer C, Mangin
JF, Chupin M, Cointepas Y, Accart B, Gelé P, Fievet F, Chabel M, Derenaucourt V,
Facon L, Njosse YT, Deplanque D, Duhamel A, Djemmane L, Duflot F.
Author information:
(1)Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS, UMR 5229,
Bron.
(2)Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de
Neurologie C, Centre Expert Parkinson NS-PARK/FCRIN network, Bron.
(3)University of Cologne, Faculty of Medicine and University Hospital Cologne,
Department of Nuclear Medicine, Cologne, Germany.
(4)Service de Neurochirurgie fonctionnelle, Hôpital Neurologique et
Neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.
(5)Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong
University School of Medicine, Shanghai, China.
(6)Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai
Jiao Tong University School of Medicine, Shanghai, China.
(7)Hospices Civils de Lyon, Service de biostatistiques, Lyon, France.
(8)Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg,
France.
(9)Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de
Strasbourg, Strasbourg, France.
(10)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC),
INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch-Graffenstaden,
France.
(11)Department of Neurosurgery, NS-PARK/F-CRIN, Strasbourg University Hospital,
Strasbourg, France.
(12)Univ Lille, CHU-Lille, Medical Pharmacology & Neurology, Expert center for
Parkinson, Lille Neuroscience & Cognition, Inserm, UMR-S1172, LICEND, NS-Park
network, Lille, France.
(13)Univ Lyon, Université Claude Bernard Lyon 1, Faculté de Médecine et de
Maïeutique Lyon Sud Charles Mérieux, Oullins.
In this one-year prospective study, Parkinson’s disease (PD) patients with or
without mania following STN-DBS were compared to investigate risk and
etiological factors, clinical management and consequences. Eighteen (16.2%) out
of 111 consecutive PD patients developed mania, of whom 17 were males. No
preoperative risk factor was identified. Postoperative mania was related to
ventral limbic subthalamic stimulation in 15 (83%) patients, and resolved as
stimulation was relocated to the sensorimotor STN, besides discontinuation or
reduction of dopamine agonists and use of low-dose clozapine in 12 patients,
while motor and nonmotor outcomes were similar. These findings underpin the
prominent role of limbic subthalamic stimulation in postoperative mania. ANN
NEUROL 2022;92:411-417.
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on
behalf of American Neurological Association.
DOI: 10.1002/ana.26434
PMID: 35703252 [Indexed for MEDLINE]