Let thy left brain know what thy right brain doeth: Inter-hemispheric compensation of functional deficits after brain damage

Paolo Bartolomeo, Michel Thiebaut de Schotten
Neuropsychologia. 2016-12-01; 93: 407-412
DOI: 10.1016/j.neuropsychologia.2016.06.016

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1. Neuropsychologia. 2016 Dec;93(Pt B):407-412. doi:
10.1016/j.neuropsychologia.2016.06.016. Epub 2016 Jun 14.

Let thy left brain know what thy right brain doeth: Inter-hemispheric
compensation of functional deficits after brain damage.

Bartolomeo P(1), Thiebaut de Schotten M(2).

Author information:
(1)INSERM U1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et
Marie Curie-Paris 6, UMRS 1127, Institut du Cerveau et de la Moelle épinière
(ICM), F-75013 Paris, France; AP-HP, Department of Neurology, IFR 70, Salpêtrière
Hospital, Paris, France.
(2)INSERM U1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et
Marie Curie-Paris 6, UMRS 1127, Institut du Cerveau et de la Moelle épinière
(ICM), F-75013 Paris, France; AP-HP, Department of Neurology, IFR 70, Salpêtrière
Hospital, Paris, France; Brain Connectivity and Behaviour, Frontlab, Brain and
Spine Institute, Paris, France. Electronic address: .

Recent evidence revealed the importance of inter-hemispheric communication for
the compensation of functional deficits after brain damage. This review
summarises the biological consequences observed using histology as well as the
longitudinal findings measured with magnetic resonance imaging methods in brain
damaged animals and patients. In particular, we discuss the impact of post-stroke
brain hyperactivity on functional recovery in relation to time. The reviewed
evidence also suggests that the proportion of the preserved functional network
both in the lesioned and in the intact hemispheres, rather than the simple lesion
location, determines the extent of functional recovery. Hence, future research
exploring longitudinal changes in patients with brain damage may unveil potential
biomarkers underlying functional recovery.

Copyright © 2016 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neuropsychologia.2016.06.016
PMID: 27312744 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus