Large-scale plurimodal networks common to listening to, producing and reading word lists: an fMRI study combining task-induced activation and intrinsic connectivity in 144 right-handers
Brain Struct Funct. 2019-09-07; 224(9): 3075-3094
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Hesling I(1)(2)(3)(4), Labache L(5)(6)(7)(8)(9), Joliot M(5)(6)(7), Tzourio-Mazoyer N(5)(6)(7).
(1)University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France. .
(2)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(3)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
(4)IMN Institut des Maladies Neurodégénératives UMR 5293, Team 5: GIN Groupe d’imagerie Neurofonctionnelle, CEA-CNRS, Université de Bordeaux, Centre Broca Nouvelle-Aquitaine-3ème étage, 146 rue Léo-Saignat-CS 61292-Case 28, 33076, Bordeaux CEDEX, France.
(5)University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
(6)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(7)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
(8)University of Bordeaux, IMB, UMR 5251, 33405, Talence, France.
(9)INRIA Bordeaux Sud-Ouest, CQFD, INRIA, UMR 5251, 33405, Talence, France.
We aimed at identifying plurimodal large-scale networks for producing, listening to and reading word lists based on the combined analyses of task-induced activation and resting-state intrinsic connectivity in 144 healthy right-handers. In the first step, we identified the regions in each hemisphere showing joint activation and joint asymmetry during the three tasks. In the left hemisphere, 14 homotopic regions of interest (hROIs) located in the left Rolandic sulcus, precentral gyrus, cingulate gyrus, cuneus and inferior supramarginal gyrus (SMG) met this criterion, and 7 hROIs located in the right hemisphere were located in the preSMA, medial superior frontal gyrus, precuneus and superior temporal sulcus (STS). In a second step, we calculated the BOLD temporal correlations across these 21 hROIs at rest and conducted a hierarchical clustering analysis to unravel their network organization. Two networks were identified, including the WORD-LIST_CORE network that aggregated 14 motor, premotor and phonemic areas in the left hemisphere plus the right STS that corresponded to the posterior human voice area (pHVA). The present results revealed that word-list processing is based on left articulatory and storage areas supporting the action-perception cycle common not only to production and listening but also to reading. The inclusion of the right pHVA acting as a prosodic integrative area highlights the importance of prosody in the three modalities and reveals an intertwining across hemispheres between prosodic (pHVA) and phonemic (left SMG) processing. These results are consistent with the motor theory of speech postulating that articulatory gestures are the central motor units on which word perception, production, and reading develop and act together.