Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors

Marsida Kallupi, Giordano de Guglielmo, Lieselot L. G. Carrette, Sierra Simpson, Jenni Kononoff, Adam Kimbrough, Lauren C. Smith, Kokila Shankar, Alicia Avelar, Dana Conlisk, Molly Brennan, Lani Tieu, Sharona Sedighim, Brent Boomhower, Lisa Maturin, McKenzie J. Fannon, Angelica Martinez, Caitlin Crook, Selen Dirik, Nathan Velarde, Paul Schweitzer, Selene Bonnet-Zahedi, Elizabeth Sneddon, Sonja Plasil, Alex A. Morgan, Dyar N. Othman, Benjamin Sichel, Beverly Peng, Apurva S. Chitre, Oksana Polesskaya, Justin Lau, Ashley Vang, Leah C. Solberg Woods, Abraham A. Palmer, Olivier George
Neuropsychopharmacol.. 2026-01-30; :
DOI: 10.1038/s41386-026-02348-8

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