Language lateralization in left-handed patients with schizophrenia
Neuropsychologia. 2011-02-01; 49(3): 313-319
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1. Neuropsychologia. 2011 Feb;49(3):313-9. doi:
10.1016/j.neuropsychologia.2010.11.025. Epub 2010 Nov 30.
Language lateralization in left-handed patients with schizophrenia.
Razafimandimby A(1), Tzourio-Mazoyer N, Mazoyer B, Maïza O, Dollfus S.
(1)Centre d’Imagerie en Neurosciences et d’Applications aux Pathologies
(CI-NAPS), UMR 6232 CNRS, CEA, Universités de Caen et Paris 5, GIP Cyceron, BP
5229, 14074 Caen Cedex, France.
We evaluated hemispheric lateralization of language production in
non-right-handed (NRH) patients with schizophrenia compared with matched
right-handed (RH) patients, NRH control, and RH control subjects. First, the
ability to generate verbs during overt training trials was checked in 78
subjects. They were then evaluated with functional magnetic resonance imaging
(fMRI) while performing a covert verb generation task. No significant
interactions between illness and handedness and no illness effect were observed
in functional asymmetry. There was significantly less leftward asymmetry of the
inferior frontal, precentral, and supramarginal gyri as well as the
intra-parietal sulcus in non-right-handers compared to right-handers taking into
account the task performances. Our findings suggested that decreased
lateralization for language production was more closely related to handedness
than to schizophrenia.
Copyright © 2010 Elsevier Ltd. All rights reserved.
PMID: 21126527 [Indexed for MEDLINE]