Isolation and structure of the Drosophila corazonin gene
Biochemical and Biophysical Research Communications. 1994-10-01; 204(1): 292-296
DOI: 10.1006/bbrc.1994.2458
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1. Biochem Biophys Res Commun. 1994 Oct 14;204(1):292-6.
Isolation and structure of the Drosophila corazonin gene.
Veenstra JA(1).
Author information:
(1)Department of Entomology, University of Arizona, Tucson 85721.
A recombinant DNA clone containing the corazonin gene was isolated from a genomic
library of Drosophila melanogaster. Its nucleotide sequence predicts a
preprocorazonin consisting of an 19 amino acid putative signal peptide, the 11
amino acid corazonin sequence, a Gly used for amidation, a Lys-Arg proteolytic
processing site, and a 39 amino acid corazonin-precursor-related peptide (CPRP).
CPRP has an internal Arg-Arg sequence and thus could possibly be further
processed into a tripeptide and a 34-mer. Neither CPRP or its possible products
are structurally related to any known neuropeptide, and their physiological
function is unknown. The structure of the predicted preprocorazonin is remarkably
similar to the preprohormone of adipokinetic hormone, which suggests that
corazonin and adipokinetic hormone have a common evolutionary origin.
DOI: 10.1006/bbrc.1994.2458
PMID: 7945373 [Indexed for MEDLINE]