Is the planum temporale surface area a marker of hemispheric or regional language lateralization?
Brain Struct Funct. 2017-11-03; :
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1. Brain Struct Funct. 2018 Apr;223(3):1217-1228. doi: 10.1007/s00429-017-1551-7.
Epub 2017 Nov 3.
Is the planum temporale surface area a marker of hemispheric or regional language
Tzourio-Mazoyer N(1)(2)(3)(4), Crivello F(5)(6)(7), Mazoyer B(5)(6)(7).
(1)Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
(2)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(3)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
(4)IMN Institut des Maladies Neurodégénératives UMR 5293, Team 5: GIN Groupe
d’imagerie Neurofonctionnelle, Centre Broca Nouvelle-Aquitaine, 3ème étage, 146
rue Léo Saignat, CS 61292, Case 28, 33076, Bordeaux Cedex, France.
(5)Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
(6)CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(7)CEA, GIN, IMN, UMR 5293, 33000, Bordeaux, France.
We investigated the association between the left planum temporale (PT) surface
area or asymmetry and the hemispheric or regional functional asymmetries during
language production and perception tasks in 287 healthy adults (BIL&GIN) who were
matched for sex and handedness. The measurements of the PT surface area were
performed after manually delineating the region using brain magnetic resonance
images (MRI) and considering the Heschl’s gyrus (HG) duplication pattern; the
measurements either included (PTtot) or did not include (PTpost) the second
gyrus. A region encompassing both the PT and HG (HGPT) was also studied.
Regardless of the ROI measured, 80% of the sample had a positive left minus right
PT asymmetry. We first tested whether the PTtot, PTpost and HGPT surface areas in
the left or right hemispheres or PT asymmetries differed in groups of individuals
varying in language lateralization by assessing their hemispheric index during a
sentence production minus word list production task. We then investigated the
association between these different measures of the PT anatomy and the regional
asymmetries measured during the task. Regardless of the anatomical definition
used, we observed no correlations between the left surface areas or asymmetries
and the hemispheric or regional functional asymmetries during the language
production task. We then performed a similar analysis using the same sample
measuring language functional lateralization during speech listening tasks (i.e.,
listening to sentences and lists of words). Although the hemispheric
lateralization during speech listening was not correlated with the left PTtot,
PTpost or HGPT surface areas or the PT asymmetries, significant positive
correlations were observed between the asymmetries in these regions and the
regional functional asymmetries measured in areas adjacent to the end of the
Sylvian fissure while participants listened to the word lists or sentences. The
PT asymmetry thus appears to be associated with the local functional asymmetries
in auditory areas but is not a marker of inter-individual variability in language