Involvement of omega-3 fatty acids in emotional responses and hyperactive symptoms
The Journal of Nutritional Biochemistry. 2010-10-01; 21(10): 899-905
DOI: 10.1016/j.jnutbio.2009.12.005
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Lavialle M(1), Denis I, Guesnet P, Vancassel S.
Author information:
(1)INRA, UR 909 Nutrition et Régulation Lipidique des Fonctions Cérébrales,
F-78352 Jouy-en-Josas, France.
Biochemical evidence suggests a role for n-3 polyunsaturated fatty acids (n-3
PUFAs) in the regulation of behavioral disturbances. A number of studies have
revealed an association between reduced n-3 PUFA levels and attention-deficit
hyperactivity disorder or depression. Here, we summarize the main findings
regarding the association between n-3 PUFA and hyperactive and emotional
disorders, and discuss potential mechanisms of action. Because the basal ganglia
are involved in the control of locomotion and emotion, we examined published
data regarding the role of n-3 PUFA in dopamine (DA) regulation in the basal
ganglia. These results are discussed in the light of recent data from our
laboratory suggesting an association between the drop in melatonin in the pineal
gland and the increase in DA in the striatum and nucleus accumbens of n-3
PUFA-deprived rodents.
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