Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
npj Parkinsons Dis.. 2024-12-30; 10(1):
DOI: 10.1038/s41531-024-00850-8
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Estaun-Panzano J(1), Nandi S(2)(3), Gresil Q(2)(3), Doudnikoff E(1), Mazzocco
C(1), Arotcarena ML(1), Canron MH(1), Dehay B(1), Cognet L(2)(3), Bezard E(4).
Author information:
(1)Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293,
F-33000, Bordeaux, France.
(2)Univ. Bordeaux, CNRS, Laboratoire Photonique, Numérique et Nanosciences, UMR
5298, F-33400, Talence, France.
(3)IOGS, CNRS, Laboratoire Photonique, Numérique et Nanosciences, UMR 5298,
F-33400, Talence, France.
(4)Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, UMR 5293,
F-33000, Bordeaux, France. .
α-synucleinopathies progression involves the spread of α-synuclein aggregates
through the extracellular space (ECS). Single-particle tracking studies showed
that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity.
To disentangle the consequences of neuronal loss versus α-synuclein-positive
intracellular assemblies formation, we performed near-infrared single-particle
tracking to characterise ECS rheology in the striatum of mouse models of
α-synucleinopathies. We showed that intracellular α-synuclein assemblies,
without neurodegeneration, suffice to alter nanoscale diffusion in the striatal
ECS.
© 2024. The Author(s).
DOI: 10.1038/s41531-024-00850-8
PMCID: PMC11686398
PMID: 39738158
Conflict of interest statement: Competing interests: E.B. is the Chief
Scientific Officer of Motac Neuroscience Ltd. All other authors declare no
competing interests.