Intermittent feeding alters sensitivity to changes in reward value
Appetite. 2017-06-01; 113: 1-6
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1. Appetite. 2017 Jun 1;113:1-6. doi: 10.1016/j.appet.2017.02.009. Epub 2017 Feb 8.
Intermittent feeding alters sensitivity to changes in reward value.
Parkes SL(1), Furlong TM(2), Black AD(2), Balleine BW(2).
(1)Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
Electronic address: .
(2)Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
The influence of binge-like feeding schedules on subsequent food-related behavior
is not well understood. We investigated the effect of repeated cycles of
restriction and refeeding on two food-related behaviors; goal-directed responding
for a palatable food reward and sensory-specific satiety. Hungry rats were
trained to perform two instrumental actions for two distinct food outcomes and
were then subjected to repeated cycles of restricted and unrestricted access to
their maintenance chow for 30-days or were maintained on food restriction.
Goal-directed control was then assessed using specific satiety-induced outcome
devaluation. Rats were given 1 h access to one of theoutcomes and were then
immediately given a choice between the two actions. Rats maintained on
restriction responded more for the valued than the devalued reward but rats with
a history of restriction and refeeding failed to show this effect. Importantly,
all rats showed sensory-specific satiety when offered a choice between the two
foods, indicating that pre-feeding selectively reduced the value of the pre-fed
food. By contrast, sensory-specific satiety was not observed in rats with a
history of intermittent feeding when the foods were offered sequentially. These
results indicate that, similar to calorically dense diets, intermittent feeding
patterns can impair the performance of goal-directed actions as well as the
ability to reject a pre-fed food when it is offered alone.
Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.
PMID: 28189750 [Indexed for MEDLINE]