Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys ( Chlorocebus sabaeus )
Lab Anim. 2025-03-13; :
DOI: 10.1177/00236772241302576
Lire sur PubMed
https://www.bordeaux-neurocampus.fr/11940
The MPTP-animal model of Parkinson’s disease has significantly advanced our understanding of Parkinson’s disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson’s disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.