Inhibitory activity of plant stilbenoids against nitric oxide production by lipopolysaccharide-activated microglia.
Planta Med. 2013-06-27; 79(11): 966-970
DOI: 10.1055/s-0032-1328651
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1. Planta Med. 2013 Jul;79(11):966-70. doi: 10.1055/s-0032-1328651. Epub 2013 Jun
27.
Inhibitory activity of plant stilbenoids against nitric oxide production by
lipopolysaccharide-activated microglia.
Nassra M(1), Krisa S, Papastamoulis Y, Kapche GD, Bisson J, André C, Konsman JP,
Schmitter JM, Mérillon JM, Waffo-Téguo P.
Author information:
(1)Groupe d’Etude des Substances Végétales à Activité Biologique, Université de
Bordeaux, Institut des Sciences de la Vigne et du Vin, Villenave d’Ornon, France.
Microglia-driven inflammatory processes are thought to play an important role in
ageing and several neurological disorders. Since consumption of a diet rich in
polyphenols has been associated with anti-inflammatory and neuroprotective
effects, we studied the effects of twenty-five stilbenoids isolated from Milicia
excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were
tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial
lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric
oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B,
were the most effective molecules. Moreover, they attenuated the expression of
the inducible NO synthase protein and gene.
Georg Thieme Verlag KG Stuttgart · New York.
DOI: 10.1055/s-0032-1328651
PMID: 23807809 [Indexed for MEDLINE]