Inhibitory activity of plant stilbenoids against nitric oxide production by lipopolysaccharide-activated microglia.
Planta Med. 2013-06-27; 79(11): 966-970
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1. Planta Med. 2013 Jul;79(11):966-70. doi: 10.1055/s-0032-1328651. Epub 2013 Jun
Inhibitory activity of plant stilbenoids against nitric oxide production by
Nassra M(1), Krisa S, Papastamoulis Y, Kapche GD, Bisson J, André C, Konsman JP,
Schmitter JM, Mérillon JM, Waffo-Téguo P.
(1)Groupe d’Etude des Substances Végétales à Activité Biologique, Université de
Bordeaux, Institut des Sciences de la Vigne et du Vin, Villenave d’Ornon, France.
Microglia-driven inflammatory processes are thought to play an important role in
ageing and several neurological disorders. Since consumption of a diet rich in
polyphenols has been associated with anti-inflammatory and neuroprotective
effects, we studied the effects of twenty-five stilbenoids isolated from Milicia
excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were
tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial
lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric
oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B,
were the most effective molecules. Moreover, they attenuated the expression of
the inducible NO synthase protein and gene.
Georg Thieme Verlag KG Stuttgart · New York.
PMID: 23807809 [Indexed for MEDLINE]