Inhibition-induced theta resonance in cortical circuits.
Neuron. 2013-12-01; 80(5): 1263-1276
DOI: 10.1016/j.neuron.2013.09.033
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1. Neuron. 2013 Dec 4;80(5):1263-76. doi: 10.1016/j.neuron.2013.09.033.
Inhibition-induced theta resonance in cortical circuits.
Stark E(1), Eichler R, Roux L, Fujisawa S, Rotstein HG, Buzsáki G.
Author information:
(1)NYU Neuroscience Institute, School of Medicine, New York University, New York,
NY 10016, USA. Electronic address: .
Both circuit and single-cell properties contribute to network rhythms. In vitro,
pyramidal cells exhibit theta-band membrane potential (subthreshold) resonance,
but whether and how subthreshold resonance translates into spiking resonance in
freely behaving animals is unknown. Here, we used optogenetic activation to
trigger spiking in pyramidal cells or parvalbumin immunoreactive interneurons
(PV) in the hippocampus and neocortex of freely behaving rodents. Individual
directly activated pyramidal cells exhibited narrow-band spiking centered on a
wide range of frequencies. In contrast, PV photoactivation indirectly induced
theta-band-limited, excess postinhibitory spiking in pyramidal cells (resonance).
PV-inhibited pyramidal cells and interneurons spiked at PV-inhibition troughs,
similar to CA1 cells during spontaneous theta oscillations. Pharmacological
blockade of hyperpolarization-activated (I(h)) currents abolished theta
resonance. Inhibition-induced theta-band spiking was replicated in a pyramidal
cell-interneuron model that included I(h). Thus, PV interneurons mediate
pyramidal cell spiking resonance in intact cortical networks, favoring
transmission at theta frequency.
Copyright © 2013 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2013.09.033
PMCID: PMC3857586
PMID: 24314731 [Indexed for MEDLINE]