Influence of ontogenetic age on the role of dentate granule neurons.

Sophie Tronel, Valérie Lemaire, Vanessa Charrier, Marie-Françoise Montaron, Djoher Nora Abrous
Brain Struct Funct. 2014-02-09; 220(2): 645-661
DOI: 10.1007/s00429-014-0715-y

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1. Brain Struct Funct. 2015 Mar;220(2):645-61. doi: 10.1007/s00429-014-0715-y. Epub
2014 Feb 9.

Influence of ontogenetic age on the role of dentate granule neurons.

Tronel S(1), Lemaire V, Charrier V, Montaron MF, Abrous DN.

Author information:
(1)Inserm U862, 33077, Bordeaux, France, .

New neurons are continuously produced in the adult dentate gyrus of the
hippocampus, a key structure in learning and memory. It has been shown that adult
neurogenesis is crucial for normal memory processing. However, it is not known
whether neurons born during the developmental period and during adulthood support
the same functions. Here, we demonstrate that neurons born in neonates (first
postnatal week) are activated in different memory processes when they are mature
compared to neurons born in adults. By imaging the activation of these two
different neuron generations in the same rat and using the IEG Zif268 and Fos, we
show that these neurons are involved in discriminating dissimilar contexts and
spatial problem solving, respectively. These findings demonstrate that the
ontogenetic stage during which neurons are generated is crucial for their
function within the memory network.

DOI: 10.1007/s00429-014-0715-y
PMID: 24510284 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus