Influence of age, circadian and homeostatic processes on inhibitory motor control: A Go/Nogo task study
PLoS ONE. 2012-06-25; 7(6): e39410
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1. PLoS One. 2012;7(6):e39410. doi: 10.1371/journal.pone.0039410. Epub 2012 Jun 25.
Influence of age, circadian and homeostatic processes on inhibitory motor
control: a Go/Nogo task study.
Sagaspe P(1), Taillard J, Amiéva H, Beck A, Rascol O, Dartigues JF, Capelli A,
(1)CNRS USR 3413 SANPSY, Sleep, Attention and NeuroPSYchiatrie, Université de
Bordeaux, Bordeaux, France.
INTRODUCTION: The contribution of circadian system and sleep pressure influences
on executive performance as a function of age has never been studied. The aim of
our study was to determine the age-related evolution of inhibitory motor control
(i.e., ability to suppress a prepotent motor response) and sustained attention
under controlled high or low sleep pressure conditions.
METHODS: 14 healthy young males (mean age = 23 ± 2.7; 20-29 years) and 11 healthy
older males (mean age = 68 ± 1.4; 66-70 years) were recruited. The volunteers
were placed for 40 hours in « constant routine ». In the « Sleep Deprivation SD »
condition, the volunteer was kept awake for 40 hours to obtain a high sleep
pressure condition interacting with the circadian process. In the « NAP »
condition, the volunteer adopted a short wake/sleep cycle (150/75 min) resulting
in a low sleep pressure condition to counteract the homeostatic pressure and
investigate the circadian process. Performances were evaluated by a simple
reaction time task and a Go/Nogo task repeated every 3H45.
RESULTS: In the SD condition, inhibitory motor control (i.e., ability to inhibit
an inappropriate response) was impaired by extended wakefulness equally in both
age groups (P