Increasing resolution in stress neurobiology: from single cells to complex group behaviors
Stress. 2023-01-02; 26(1):
DOI: 10.1080/10253890.2023.2186141
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Miranda L(1)(2), Bordes J(3), Gasperoni S(4), Lopez JP(4).
Author information:
(1)Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.
(2)International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
(3)Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
(4)Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stress can have severe psychological and physiological consequences. Thus,
inappropriate regulation of the stress response is linked to the etiology of
mood and anxiety disorders. The generation and implementation of preclinical
animal models represent valuable tools to explore and characterize the
mechanisms underlying the pathophysiology of stress-related psychiatric
disorders and the development of novel pharmacological strategies. In this
commentary, we discuss the strengths and limitations of state-of-the-art
molecular and computational advances employed in stress neurobiology research,
with a focus on the ever-increasing spatiotemporal resolution in cell biology
and behavioral science. Finally, we share our perspective on future directions
in the fields of preclinical and human stress research.