Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice.
PLoS ONE. 2009-06-23; 4(6): e6006
Lire sur PubMed
1. PLoS One. 2009 Jun 23;4(6):e6006. doi: 10.1371/journal.pone.0006006.
Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated
with a spatial memory deficit in P2X(7) receptor-deficient mice.
Labrousse VF(1), Costes L, Aubert A, Darnaudéry M, Ferreira G, Amédée T, Layé S.
(1)Psychoneuroimmunologie, Nutrition et Génétique (PsyNuGen), INRA UMR 1286, CNRS
UMR 5226, Université de Bordeaux, Bordeaux, France.
Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally
identified as a proinflammatory cytokine, is also required in the brain for
memory processes. We have previously shown that IL-1beta synthesis in the
hippocampus is dependent on P2X(7) receptor (P2X(7)R), which is an ionotropic
receptor of ATP. To substantiate the role of P2X(7)R in both brain IL-1beta
expression and memory processes, we examined the induction of IL-1beta mRNA
expression in the hippocampus of wild-type (WT) and homozygous P2X(7) receptor
knockout mice (P2X(7)R(-/-)) following a spatial memory task. The spatial
recognition task induced both IL-1beta mRNA expression and c-Fos protein
activation in the hippocampus of WT but not of P2X(7)R(-/-) mice. Remarkably,
P2X(7)R(-/-) mice displayed spatial memory impairment in a hippocampal-dependant
task, while their performances in an object recognition task were unaltered.
Taken together, our results show that P2X(7)R plays a critical role in spatial
memory processes and the associated hippocampal IL-1beta mRNA synthesis and c-Fos
PMID: 19547756 [Indexed for MEDLINE]