Impact of sleep apnea syndrome on survival in patients with multiple system atrophy.
Parkinsonism & Related Disorders. 2017-02-01; 35: 92-95
DOI: 10.1016/j.parkreldis.2016.12.013
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1. Parkinsonism Relat Disord. 2017 Feb;35:92-95. doi:
10.1016/j.parkreldis.2016.12.013. Epub 2016 Dec 16.
Impact of sleep apnea syndrome on survival in patients with multiple system
atrophy.
Flabeau O(1), Ghorayeb I(2), Perez P(3), Maillard A(3), Taillard J(4), Philip
P(4), Foubert-Samier A(5), Tison F(5), Meissner WG(6).
Author information:
(1)Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France.
(2)Department of Clinical Neurophysiology, University Hospital Bordeaux, France;
CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR
5287, Université de Bordeaux, Bordeaux, France.
(3)CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique
(USMR), Pôle de santé publique, Bordeaux, France.
(4)Univ. Bordeaux, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000
Bordeaux, France; CNRS, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000
Bordeaux, France.
(5)Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de
Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux,
France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000
Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de
Bordeaux, F-33076 Bordeaux, France.
(6)Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de
Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux,
France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000
Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de
Bordeaux, F-33076 Bordeaux, France. Electronic address:
.
INTRODUCTION: Sleep apnea is very frequent in multiple system atrophy (MSA) and
may contribute to the poor prognosis. The aim of the present study was to
prospectively assess the relation between sleep apnea and survival in 30
consecutive MSA patients recruited at the French Reference Center for MSA.
METHODS: Patients with « probable » MSA according to current consensus diagnosis
criteria were enrolled in this prospective cohort study. All patients received
full polysomnography at baseline and were then followed for up to 4.5 years. The
prognostic role of sleep apnea was assessed by a Cox model in an univariate
analysis and then adjusted on other potential factors.
RESULTS: Analyzable polysomnographic recordings were available for 28 patients.
Sleep apnea was found in 11 patients. During follow-up, 15 patients died,
including 9 with baseline sleep apnea. In an univariate analysis, sleep apnea,
Unified MSA Rating Scale I + II score at baseline and at year one, and disease
duration were associated with mortality. However, when adjusting for disease
duration and baseline Unified MSA Rating Scale score, the association between
sleep apnea and mortality was no longer significant.
CONCLUSIONS: Sleep apnea was not an independent factor associated with mortality
in this prospective cohort study.
Copyright © 2016 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.parkreldis.2016.12.013
PMID: 28011164 [Indexed for MEDLINE]