Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System.
eNeuro. 2017-01-01; 4(3): ENEURO.0120-17.2017
DOI: 10.1523/eneuro.0120-17.2017
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1. eNeuro. 2017 Jun 1;4(3). pii: ENEURO.0120-17.2017. doi:
10.1523/ENEURO.0120-17.2017. eCollection 2017 May-Jun.
Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic
System.
Naneix F(1)(2), Tantot F(1)(3), Glangetas C(1)(4), Kaufling J(1)(4), Janthakhin
Y(1)(3), Boitard C(1)(3), De Smedt-Peyrusse V(1)(3), Pape JR(1)(2), Vancassel
S(1)(3), Trifilieff P(1)(3), Georges F(1)(4), Coutureau E(1)(2), Ferreira
G(1)(3).
Author information:
(1)Université de Bordeaux, 33077 Bordeaux, France.
(2)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287, 33077 Bordeaux, France.
(3)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33077 Bordeaux, France.
(4)CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33077 Bordeaux,
France.
Increasing evidence suggest that consumption of high-fat diet (HFD) can impact
the maturation of brain circuits, such as during adolescence, which could account
for behavioral alterations associated with obesity. In the present study, we used
behavioral sensitization to amphetamine to investigate the effect of
periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine
(DA) system, a central actor in food reward processing. pHFD does not affect
responding to an acute injection, however, a single exposure to amphetamine is
sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by
rapid neurobiological adaptations within the DA system. In pHFD-exposed animals,
a single amphetamine exposure induces an increase in bursting activity of DA
cells in the ventral tegmental area (VTA) as well as higher DA release and
greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc).
Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos
expression after amphetamine injection. These findings highlight the
vulnerability of DA system to the consumption of HFD during adolescence that may
support deficits in reward-related processes observed in obesity.
DOI: 10.1523/ENEURO.0120-17.2017
PMCID: PMC5454405
PMID: 28580417 [Indexed for MEDLINE]