IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C.

Matthias Majer, Leonie A.M. Welberg, Lucile Capuron, Giuseppe Pagnoni, Charles L. Raison, Andrew H. Miller
Brain, Behavior, and Immunity. 2008-08-01; 22(6): 870-880
DOI: 10.1016/j.bbi.2007.12.009

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1. Brain Behav Immun. 2008 Aug;22(6):870-80. doi: 10.1016/j.bbi.2007.12.009. Epub
2008 Feb 6.

IFN-alpha-induced motor slowing is associated with increased depression and
fatigue in patients with chronic hepatitis C.

Majer M(1), Welberg LA, Capuron L, Pagnoni G, Raison CL, Miller AH.

Author information:
(1)Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute,
Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA 30322, USA.

Interferon (IFN)-alpha has been used to investigate pathways by which innate
immune cytokines influence the brain and behaviour. Previous studies suggest that
altered basal ganglia function may contribute to IFN-alpha-induced
neuropsychological and behavioural changes. To further examine IFN-alpha effects
on neuropsychological functions related to basal ganglia (as well as other brain
regions), and explore the relationship between altered neuropsychological
function and IFN-alpha-induced depression and fatigue, a selected subset of the
Cambridge Neuropsychological Test Automated Battery was administered to 32
hepatitis C patients at baseline (Visit 1) and following approximately 12 weeks
(Visit 2) of either no treatment (n=12) or treatment with IFN-alpha plus
ribavirin (n=20). Symptoms of depression and fatigue were assessed using the
Montgomery-Asberg Depression Rating Scale and the Multidimensional Fatigue
Inventory. Compared to control subjects, patients treated with
IFN-alpha/ribavirin exhibited significant decreases in motor speed as measured in
the simple and five-choice movement segments of the CANTAB reaction time task and
slower response times in the rapid visual information processing task, a task of
sustained attention. Decreased motor speed on the five-choice movement segments
of the reaction time task was in turn correlated with increased symptoms of
depression and fatigue (R=0.47, p

Auteurs Bordeaux Neurocampus