How verbal and spatial manipulation networks contribute to calculation: an fMRI study.

Laure Zago, Laurent Petit, Marie-Renée Turbelin, Frédéric Andersson, Mathieu Vigneau, Nathalie Tzourio-Mazoyer
Neuropsychologia. 2008-07-01; 46(9): 2403-2414
DOI: 10.1016/j.neuropsychologia.2008.03.001

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1. Neuropsychologia. 2008;46(9):2403-14. doi:
10.1016/j.neuropsychologia.2008.03.001. Epub 2008 Mar 18.

How verbal and spatial manipulation networks contribute to calculation: an fMRI

Zago L(1), Petit L, Turbelin MR, Andersson F, Vigneau M, Tzourio-Mazoyer N.

Author information:
(1)CI-NAPS UMR 6232, CNRS, CEA, Université Caen Basse Normandie, Université Paris
Descartes, France.

The manipulation of numbers required during calculation is known to rely on
working memory (WM) resources. Here, we investigated the respective contributions
of verbal and/or spatial WM manipulation brain networks during the addition of
four numbers performed by adults, using functional magnetic resonance imaging
(fMRI). Both manipulation and maintenance tasks were proposed with syllables,
locations, or two-digit numbers. As compared to their maintenance, numbers
manipulation (addition) elicited increased activation within a widespread
cortical network including inferior temporal, parietal, and prefrontal regions.
Our results demonstrate that mastery of arithmetic calculation requires the
cooperation of three WM manipulation systems: an executive manipulation system
conjointly recruited by the three manipulation tasks, including the anterior
cingulate cortex (ACC), the orbital part of the inferior frontal gyrus, and the
caudate nuclei; a left-lateralized, language-related, inferior fronto-temporal
system elicited by numbers and syllables manipulation tasks required for
retrieval, selection, and association of symbolic information; and a right
superior and posterior fronto-parietal system elicited by numbers and locations
manipulation tasks for spatial WM and attentional processes. Our results provide
new information that the anterior intraparietal sulcus (IPS) is involved in tasks
requiring a magnitude processing with symbolic (numbers) and nonsymbolic
(locations) stimuli. Furthermore, the specificity of arithmetic processing is
mediated by a left-hemispheric specialization of the anterior and posterior parts
of the IPS as compared to a spatial task involving magnitude processing with
nonsymbolic material.

DOI: 10.1016/j.neuropsychologia.2008.03.001
PMID: 18406434 [Indexed for MEDLINE]

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