Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition
Neurobiology of Aging. 2014-09-01; 35(9): 2118-2125
DOI: 10.1016/j.neurobiolaging.2014.03.021
Lire sur PubMed
1. Neurobiol Aging. 2014 Sep;35(9):2118-25. doi:
10.1016/j.neurobiolaging.2014.03.021. Epub 2014 Mar 22.
Hippocampal perivascular spaces are related to aging and blood pressure but not
to cognition.
Yao M(1), Zhu YC(2), Soumaré A(3), Dufouil C(3), Mazoyer B(4), Tzourio C(3),
Chabriat H(5).
Author information:
(1)Department of Neurology, Peking Union Medical College Hospital, Beijing,
China; Univ Paris Diderot, Sorbonne Paris Cité, Paris, France.
(2)Department of Neurology, Peking Union Medical College Hospital, Beijing,
China.
(3)Univ Pierre et Marie Curie Paris 6, Paris, France; INSERM UMR708, Bordeaux,
France.
(4)Institut Universitaire de France, Paris, France; CNRS-CEA UMR 6232, Caen,
France; Groupe Imagerie Neurofonctionelle, Caen, France; University Caen
Basse-Normandie, Caen, France; CHU de Caen, Caen, France.
(5)Univ Paris Diderot, Sorbonne Paris Cité, Paris, France; INSERM UMR 1161 and
DHU NeuroVasc, Paris, France; Department of Neurology, AP-HP, Paris, France.
Electronic address: .
The risk factors of hippocampal dilated perivascular spaces (H-dPVS), their
radiological relevance and their impact on cognitive performance remain under
investigation. These aspects were evaluated in 1818 stroke- and dementia-free
participants enrolled in the 3C-Dijon MRI study, using logistic regression,
multiple linear regression, and Cox models. At study entry, the load of H-dPVS
was found strongly associated with age and hypertension (degree 2 vs. degree 0:
odds ratio: 1.16; 95% confidence interval: 1.02-1.33 and odds ratio: 1.98; 95%
confidence interval: 1.39-2.81, respectively) and positively related to the
presence of lacunar infarcts, white-matter hyperintensities volume, and
hippocampal volume (p ≤ 0.024). Load of H-dPVS was not related to baseline
cognitive performance (p > 0.05). Cox regression modeling did not show a
significant relationship between the load of H-dPVS and incident dementia risk (p
> 0.05). The present results support that both aging and blood pressure do play a
key role in the development of H-dPVS in the older population. In contrast with
the dilated perivascular spaces located in white matter or basal ganglia, the
load of H-dPVS does not appear associated with occurrence of dementia.
Copyright © 2014 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neurobiolaging.2014.03.021
PMID: 24731517 [Indexed for MEDLINE]