Hippocampal morphology and spatially related behavior in Long-Evans and CFY rats.
Hippocampus. 1993-01-01; 3(1): 1-7
DOI: 10.1002/hipo.450030102
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1. Hippocampus. 1993 Jan;3(1):1-7.
Hippocampal morphology and spatially related behavior in Long-Evans and CFY rats.
Schwegler H(1), Mueller GG, Crusio WE, Szemes L, Seress L.
Author information:
(1)Institute of Anatomy, University of Freiburg, Germany.
Behavioral responses to novelty in an open field and spatial learning in a radial
maze with four arms out of eight reinforced were tested in male and female CFY
and Long-Evans rats. Subsequently, the sizes of the total hippocampi and of
various hippocampal cell layers and terminal fields at the midseptotemporal level
were measured in Timm-stained sections. No strain differences were found in the
open field (except for defecation). In the radial maze, Long-Evans rats showed
better spatial reference memory capabilities than rats of the CFY strain. The
relative sizes of the intra- and infrapyramidal mossy fiber (IIP-MF) projections
did not differ between the strains. Within the more variable CFY strain, a
positive correlation between the size of the IIP-MF projection and radial maze
performance was found. The absolute sizes of the entire hippocampi and all
hippocampal layers at the midseptotemporal level were larger in the CFY strain.
The size of the suprapyramidal mossy fiber projection was related to the number
of granule cells and to the ratio between granule and CA3 pyramidal cells. In
contrast, the size of the IIP-MF projection did not correlate with either of
these variables. The results indicate that the size of the mossy fiber projection
may be determined mainly by the available postsynaptic surface on the dendrites
of CA3 pyramidal neurons. Furthermore, an increased number of granule cells and
their larger projection to the apical dendrites of pyramidal neurons does not
appear to result in physiological changes with behavioral consequences.(ABSTRACT
TRUNCATED AT 250 WORDS)
DOI: 10.1002/hipo.450030102
PMID: 8364679 [Indexed for MEDLINE]