High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome.
BMC Cardiovasc Disord. 2015-03-18; 15(1):
DOI: 10.1186/s12872-015-0015-3
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1. BMC Cardiovasc Disord. 2015 Mar 18;15:23. doi: 10.1186/s12872-015-0015-3.
High sensitivity C reactive protein, fibrinogen levels and the onset of major
depressive disorder in post-acute coronary syndrome.
Lafitte M(1), Tastet S(2), Perez P(3), Serisé MA(4), Grandoulier AS(5),
Aouizerate B(6), Sibon I(7), Capuron L(8), Couffinhal T(9)(10)(11).
Author information:
(1)CHU de Bordeaux, Centre d’Exploration, de Prévention et de Traitement de
l’Athéroclérose, CEPTA, Hôpital Cardiologique du Haut-Lévêque, Avenue de
Magellan, 33604 PESSAC Cedex, F-33000, Bordeaux, France.
.
(2)CHU de Bordeaux, Centre d’Exploration, de Prévention et de Traitement de
l’Athéroclérose, CEPTA, Hôpital Cardiologique du Haut-Lévêque, Avenue de
Magellan, 33604 PESSAC Cedex, F-33000, Bordeaux, France.
.
(3)CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique et
Epidémiologique, F-33000, Bordeaux, France. .
(4)CHU de Bordeaux, Centre d’Exploration, de Prévention et de Traitement de
l’Athéroclérose, CEPTA, Hôpital Cardiologique du Haut-Lévêque, Avenue de
Magellan, 33604 PESSAC Cedex, F-33000, Bordeaux, France. .
(5)CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique et
Epidémiologique, F-33000, Bordeaux, France.
.
(6)CHU de Bordeaux, Pôle Universitaire de Psychiatrie, F-33000, Bordeaux, France.
.
(7)CHU de Bordeaux, Unité Neurovasculaire, F-33000, Bordeaux, France.
.
(8)INRA, Nutrition et Neurobiologie intégrée, UMR 1286, F-33000, Bordeaux,
France. .
(9)CHU de Bordeaux, Centre d’Exploration, de Prévention et de Traitement de
l’Athéroclérose, CEPTA, Hôpital Cardiologique du Haut-Lévêque, Avenue de
Magellan, 33604 PESSAC Cedex, F-33000, Bordeaux, France.
.
(10)Univ. Bordeaux, Adaptation cardiovasculaire à l’ischémie, U1034, F-33600,
Pessac, France. .
(11)INSERM, Adaptation cardiovasculaire à l’ischémie, U1034, F-33600, Pessac,
France. .
BACKGROUND: Major depression disorder (MDD) is a common condition in patients
suffering from acute coronary syndrome (ACS), and depression is a risk factor for
mortality following an ACS. Growing evidence suggests that there is an intricate
interplay between atherosclerosis, inflammation and depression. The aim of this
study was to investigate the role of atherosclerosis-induced inflammation in the
mediation of MDD.
METHODS: 87 patients without depression were recruited at the time of an ACS,
evaluated at 3 and 7 days and followed at 1, 3 and 9 months for the occurrence of
a MDD as assessed by structured interviews (MINI). At each time point, they were
monitored for inflammatory markers (high sensitivity C Reactive Protein {hsCRP}
and fibrinogen), cardiovascular risk factors and atherosclerosis burden.
Association between possible predictive characteristics and depression was
assessed using a multivariable logistic regression model.
RESULTS: The overall incidence of MDD, in this population, was 28.7% [95% CI:
19.5 – 39.4] during the 9-month follow up period. Elevated hsCRP was not
associated with depression onset after an ACS (adjusted OR: 1.07 [0.77 – 1.48]; p
= 0.70), and similarly no association was found with fibrinogen. Furthermore, we
found no association between hsCRP, fibrinogen or atherosclerosis burden at any
time-point, and the occurrence of a MDD (or HDRS-17 and MADRS). The only factor
associated with depression occurrence after an ACS was a previous personal
history of depression (adjusted OR: 11.02 [2.74 to 44.34]; p = 0.0007).
CONCLUSIONS: The present study shows that after an ACS, patients treated with
optimal medications could have a MDD independent of elevated hsCRP or fibrinogen
levels. Personal history of depression may be a good marker to select patients
who should be screened for depression after an ACS.
DOI: 10.1186/s12872-015-0015-3
PMCID: PMC4436867
PMID: 25888123 [Indexed for MEDLINE]