High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice
Sci Rep. 2016-09-23; 6(1):
DOI: 10.1038/srep34011
Lire sur PubMed
Type 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic,
has been correlated with lower olfactory abilities in humans. As olfaction
represents a major component of feeding behavior, its alteration may have drastic
consequences on feeding behaviors that may in turn aggravates T2D. In order to
decipher the impact of T2D on the olfactory epithelium, we fed mice with a high
fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4
weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral
capacities. Consistently, this decline in olfactory behavior was correlated to
decreased electrophysiological responses of olfactory neurons recorded as a
population and individually. Our results demonstrate that, in rodents, olfaction
is modified by HFruD-induced diabetes. Functional, anatomical and behavioral
changes occurred in the olfactory system at a very early stage of the disease.