High frequency stimulation of the subthalamic nucleus modulates neurotransmission in limbic brain regions of the rat

Christine Winter, Christoph Lemke, Reinhard Sohr, Wassilios Meissner, Daniel Harnack, Georg Juckel, Rudolf Morgenstern, Andreas Kupsch
Exp Brain Res. 2007-10-26; 185(3): 497-507
DOI: 10.1007/s00221-007-1171-1

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1. Exp Brain Res. 2008 Mar;185(3):497-507. Epub 2007 Oct 26.

High frequency stimulation of the subthalamic nucleus modulates neurotransmission
in limbic brain regions of the rat.

Winter C(1), Lemke C, Sohr R, Meissner W, Harnack D, Juckel G, Morgenstern R,
Kupsch A.

Author information:
(1)Department of Neurology, Charité Campus Virchow, Berlin, Germany.
*protected email*

Despite the benefit high frequency stimulation (HFS) of the subthalamic nucleus
(STN) has on motor symptoms of Parkinson’s Disease (PD), accumulating data also
suggest effects of STN-HFS on non-motor behavior. This may be related to the
involvement of the STN in the limbic basal ganglia-thalamocortical loops. In the
present study we investigated the effect of acute STN-HFS on neurotransmission in
associated structures of these pathways, i.e. the nucleus accumbens (NAc) core
and shell as well as the ventral tegmental area (VTA) using in vivo
microdialysis. Experiments were performed in anaesthetized naive rats and rats
selectively lesioned in the substantia nigra pars compacta (SNc) or VTA. We
demonstrate that: 1. STN-HFS leads to an increase in DA in the NAc, 2., these
effects are more pronounced in the NAc shell than in the NAc core, 3. STN-HFS
leads to a decrease in GABA in the VTA, 4. preceding lesion of the SNc does not
seem to affect the effect of STN-HFS on accumbal DA transmission whereas 5.
preceding lesion of the VTA seems to prohibit further detection of DA in the NAc.
We conclude that STN-HFS significantly affects neurotransmission in the limbic
system, which might contribute to explain the non-motor effects of STN-HFS.

DOI: 10.1007/s00221-007-1171-1
PMID: 17962928 [Indexed for MEDLINE]


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