Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis.
Neuropsychopharmacol. 2009-11-04; 35(3): 686-691
DOI: 10.1038/npp.2009.175
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Rotge JY(1), Langbour N, Guehl D, Bioulac B, Jaafari N, Allard M, Aouizerate B,
Burbaud P.
Author information:
(1)Laboratoire Mouvement Adaptation Cognition, CNRS UMR 5227, Université
Bordeaux 2, Bordeaux, France.
Many voxel-based morphometry (VBM) studies have found abnormalities in gray
matter density (GMD) in obsessive-compulsive disorder (OCD). Here, we performed
a quantitative meta-analysis of VBM studies contrasting OCD patients with
healthy controls (HC). A literature search identified 10 articles that included
343 OCD patients and 318 HC. Anatomic likelihood estimation meta-analyses were
performed to assess GMD changes in OCD patients relative to HC. GMD was smaller
in parieto-frontal cortical regions, including the supramarginal gyrus, the
dorsolateral prefrontal cortex, and the orbitofrontal cortex, and greater in the
basal ganglia (putamen) and the anterior prefrontal cortex in OCD patients
relative to HC. No significant differences were found between children and
adults. Our findings indicate differences in GMD in parieto-frontal areas and
the basal ganglia between OCD patients and HC. We conclude that structural
abnormalities within the prefrontal-basal ganglia network are involved in OCD
pathophysiology.
DOI: 10.1038/npp.2009.175
PMCID: PMC3055616
PMID: 19890260 [Indexed for MEDLINE]