Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease
Cell Metabolism. 2022-05-01; 34(5): 654-655
DOI: 10.1016/j.cmet.2022.04.002
1. Cell Metab. 2022 May 3;34(5):654-655. doi: 10.1016/j.cmet.2022.04.002.
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s
disease.
Bonvento G(1), Oliet SHR(2), Panatier A(2).
Author information:
(1)Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies
Neurodégénératives, Fontenay-aux-Roses, France. Electronic address:
.
(2)Université de Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux,
France.
Comment on
Cell Metab. 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.
Recent work from Bonvento and colleagues indicated that synaptic and memory
deficits in early Alzheimer’s disease (AD) are related to a shortage in L-serine
production in astrocytes. Here, the authors, responding to correspondence from
Chen and colleagues, discuss how this deficiency does not necessarily require a
decrease in PHGDH expression and conclude that the primary event leading to
lower serine production is more likely related to altered glycolytic flux in
early AD than to PHGDH expression.
Copyright © 2022 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.cmet.2022.04.002
PMID: 35508106 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests The authors declare no
competing interests.