GluR6/KA2 kainate receptors mediate slow-deactivating currents

A. Barberis, S. Sachidhanandam, C. Mulle
Journal of Neuroscience. 2008-06-18; 28(25): 6402-6406
DOI: 10.1523/JNEUROSCI.1204-08.2008

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1. J Neurosci. 2008 Jun 18;28(25):6402-6. doi: 10.1523/JNEUROSCI.1204-08.2008.

GluR6/KA2 kainate receptors mediate slow-deactivating currents.

Barberis A(1), Sachidhanandam S, Mulle C.

Author information:
(1)Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la
Recherche Scientifique Unité Mixte de Recherche 5091, Bordeaux Neuroscience
Institute, University of Bordeaux 2, 33077 Bordeaux, France.

Kainate receptors (KARs) are ionotropic glutamate receptors contributing to EPSCs
with a slow-decaying component that is likely essential for synaptic integration.
The slow kinetics of KAR-EPSCs markedly contrasts with the fast kinetics reported
for recombinant KARs expressed in heterologous systems, for reasons that remain
unexplained. Here we have studied the properties of recombinant heteromeric
GluR6/KA2 receptors, which compose synaptic KARs. We report that, in response to
brief glutamate applications, currents mediated by recombinant GluR6/KA2
receptors, but not GluR6 receptors, decay with a time course similar to
KAR-EPSCs. Model simulations suggest that, after brief agonist exposures,
GluR6/KA2 currents undergo slow deactivation caused by the stabilization of
partially bound open states. We propose, therefore, that the GluR6/KA2 gating
features could contribute to the slow KAR-EPSC decay kinetics.

DOI: 10.1523/JNEUROSCI.1204-08.2008
PMID: 18562611 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus