Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice.
Neurobiology of Learning and Memory. 2000-01-01; 73(1): 31-48
DOI: 10.1006/nlme.1999.3919
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1. Neurobiol Learn Mem. 2000 Jan;73(1):31-48.
Genetic differences in response to novelty and spatial memory using a two-trial
recognition task in mice.
Dellu F(1), Contarino A, Simon H, Koob GF, Gold LH.
Author information:
(1)Department of Neuropharmacology, The Scripps Research Institute, 10550 North
Torrey Pines Road, La Jolla, California 92037, USA.
A two-trial memory task, based on a free-choice exploration paradigm in a Y-maze,
was previously developed to study recognition processes in Sprague-Dawley rats.
Because this paradigm avoids the use of electric shock or deprivation that may
have nonspecific effects and does not require learning of a rule, it may be
particularly useful for studying memory in mice. Four inbred strains (Balb/cByJ,
DBA/2J, C57BL/6J, and SJL/J), an F1 hybrid (C57BL/6 x SJL/J), and one outbred
strain (CD1) were used to validate this task in mice and to characterize a strain
distribution in response to novelty and working memory. Exploration was measured
with a short (2 min) intertrial interval (ITI) between acquisition and retrieval,
while memory was examined with longer intervals (30 min, 1 h, and 2 h). A study
of the time course of the response to novelty revealed varying degrees of
preference and/or habituation to novelty among the different strains, with CD1
exhibiting a very high response to novelty and others showing lower (C57 x SJL
hybrids) to complete absence (SJL) of exploration of novelty. Memory span,
assessed with increasing ITIs, varied widely among strains from 30 min (C57 x SJL
hybrids) to at least 2 h (C57 and BALB). Such demonstrated sensitivity to a wide
range of behavioral phenotypes supports the use of this spatial memory task as an
effective tool for the study of genetic influences on the response to novelty and
recognition processes in mice.
Copyright 2000 Academic Press.
DOI: 10.1006/nlme.1999.3919
PMID: 10686122 [Indexed for MEDLINE]