Gene-environment interaction in programming hippocampal plasticity: focus on adult neurogenesis

Muriel Koehl
Front. Mol. Neurosci.. 2015-08-04; 8:
DOI: 10.3389/fnmol.2015.00041

PubMed
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1. Front Mol Neurosci. 2015 Aug 4;8:41. doi: 10.3389/fnmol.2015.00041. eCollection
2015.

Gene-environment interaction in programming hippocampal plasticity: focus on
adult neurogenesis.

Koehl M(1).

Author information:
(1)INSERM U862, Magendie Neurocenter, Neurogenesis and Pathophysiology Group,
Institut F. Magendie Bordeaux Cedex, France ; Université de Bordeaux Bordeaux,
France.

Interactions between genes and environment are a critical feature of development
and both contribute to shape individuality. They are at the core of vulnerability
resiliency for mental illnesses. During the early postnatal period, several brain
structures involved in cognitive and emotional processing, such as the
hippocampus, still develop and it is likely that interferences with this neuronal
development, which is genetically determined, might lead to long-lasting
structural and functional consequences and increase the risk of developing
psychopathology. One particular target is adult neurogenesis, which is involved
in the regulation of cognitive and emotional processes. Insights into the dynamic
interplay between genes and environmental factors in setting up individual rates
of neurogenesis have come from laboratory studies exploring experience-dependent
changes in adult neurogenesis as a function of individual’s genetic makeup. These
studies have implications for our understanding of the mechanisms regulating
adult neurogenesis, which could constitute a link between environmental
challenges and psychopathology.

DOI: 10.3389/fnmol.2015.00041
PMCID: PMC4523721
PMID: 26300723

Auteurs Bordeaux Neurocampus