Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
NeuroImage. 2006-05-01; 31(1): 419-428
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1. Neuroimage. 2006 May 15;31(1):419-28. Epub 2006 Jan 19.
Functional imaging of working memory following normal sleep and after 24 and 35 h
of sleep deprivation: Correlations of fronto-parietal activation with
Chee MW(1), Chuah LY, Venkatraman V, Chan WY, Philip P, Dinges DF.
(1)Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, 7
Hospital Drive, #01-11, Singapore 169611, Singapore.
Working memory was evaluated after normal sleep, and at 24 and 35 h of sleep
deprivation (SD) in 26 healthy young adults to examine the neural correlates of
inter-individual differences in performance. The extent of performance decline
was not significantly different between the two SD test periods although there
was greater variability in performance at SD35. In both SD sessions, there was
reduced task-related activation (relative to normal sleep) in both superior
parietal regions and the left thalamus. Activation of the left parietal and left
frontal regions after normal sleep was negatively correlated with performance
accuracy decline from normal sleep to SD24 thus differentiating persons who
maintained working memory performance following SD from those who were vulnerable
to its effects.
PMID: 16427321 [Indexed for MEDLINE]