Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task
AJP. 2007-04-01; 164(4): 638-646
DOI: 10.1176/ajp.2007.164.4.638
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1. Am J Psychiatry. 2007 Apr;164(4):638-46. doi: 10.1176/ajp.2007.164.4.638.
Fronto-striatal overactivation in euthymic bipolar patients during an emotional
go/nogo task.
Wessa M(1), Houenou J, Paillère-Martinot ML, Berthoz S, Artiges E, Leboyer M,
Martinot JL.
Author information:
(1)Inserm U797, CEA-INSERM Research Unit Neuroimaging and Psychiatry, IFR49,
University Paris-Sud 11 and University Paris 5, Hospital Department Frédéric
Joliot, 91401 Orsay, France.
OBJECTIVE: Although euthymic bipolar patients show minimal manic and depressive
symptoms, they continue to show impaired emotional regulation and cognitive
functioning. Few studies have directly examined the interference of emotional
information with cognitive processes and its underlying cerebral mechanisms in
euthymic bipolar patients. The authors examined the emotional modulation of
cognitive processes and its underlying neural mechanisms in euthymic bipolar
patients.
METHOD: Seventeen euthymic bipolar patients and 17 healthy comparison subjects
underwent functional magnetic resonance imaging (MRI) while performing an
emotional and nonemotional go/nogo task. Neural responses associated with the
overall task performance, as well as with the impact of emotional information on
the task performance, were assessed.
RESULTS: Bipolar disorder patients exhibited increased activity in the temporal
cortex, specifically to emotional go/nogo conditions, as well as in the
orbitofrontal cortex, the insula, the caudate nuclei, and the dorsal anterior
and posterior cingulate cortices when inhibiting emotional stimuli compared with
neutral stimuli. Conversely, no global attentional deficits were observed on
either a behavioral or neural response level, indicated by similar task
performances for all task conditions and similar brain activation patterns when
comparing all the go/nogo conditions with the resting state.
CONCLUSIONS: The present study provides evidence of an altered emotional
modulation of cognitive processing in euthymic bipolar patients, indicated by an
overactivation in ventral-limbic, temporal, and dorsal brain structures during
emotional go/nogo conditions in patients relative to comparison subjects.
DOI: 10.1176/ajp.2007.164.4.638
PMID: 17403978 [Indexed for MEDLINE]