Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience

H. Hirase, X. Leinekugel, A. Czurko, J. Csicsvari, G. Buzsaki
Proceedings of the National Academy of Sciences. 2001-07-24; 98(16): 9386-9390
DOI: 10.1073/pnas.161274398

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1. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9386-90. Epub 2001 Jul 24.

Firing rates of hippocampal neurons are preserved during subsequent sleep
episodes and modified by novel awake experience.

Hirase H(1), Leinekugel X, Czurkó A, Csicsvari J, Buzsáki G.

Author information:
(1)Center for Molecular and Behavioral Neuroscience, Rutgers, State University of
New Jersey, 197 University Avenue, Newark, NJ 07102, USA.

What determines the firing rate of cortical neurons in the absence of external
sensory input or motor behavior, such as during sleep? Here we report that, in a
familiar environment, the discharge frequency of simultaneously recorded
individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly
correlated across sleep-wake-sleep sequences. However, both measures were
affected when new sets of neurons were activated in a novel environment.
Nevertheless, the grand mean firing rate of the whole pyramidal cell population
remained constant across behavioral states and testing conditions. The findings
suggest that long-term firing patterns of single cells can be modified by
experience. We hypothesize that increased firing rates of recently used neurons
are associated with a concomitant decrease in the discharge activity of the
remaining population, leaving the mean excitability of the hippocampal network
unaltered.

DOI: 10.1073/pnas.161274398
PMCID: PMC55430
PMID: 11470910 [Indexed for MEDLINE]


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