Finding of endocannabinoids in human eye tissues: Implications for glaucoma
Biochemical and Biophysical Research Communications. 2005-05-01; 330(4): 1062-1067
DOI: 10.1016/j.bbrc.2005.03.095
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1. Biochem Biophys Res Commun. 2005 May 20;330(4):1062-7. doi:
10.1016/j.bbrc.2005.03.095.
Finding of endocannabinoids in human eye tissues: implications for glaucoma.
Chen J(1), Matias I, Dinh T, Lu T, Venezia S, Nieves A, Woodward DF, Di Marzo V.
Author information:
(1)Department of Biological Sciences, Allergan Inc., Irvine, CA, USA.
Cannabinoid CB(1) receptors are involved in ocular physiology and may regulate
intraocular pressure (IOP). However, endocannabinoid levels in human ocular
tissues of cornea, iris, ciliary body, retina, and choroid from normal and
glaucomatous donors have not been investigated. Anandamide
(N-arachidonoylethanolamine; AEA), 2-arachidonoylglycerol (2-AG), and the
anandamide congener, palmitoylethanolamide (PEA), were detected in all the human
tissues examined. In eyes from patients with glaucoma, significantly decreased
2-AG and PEA levels were detected in the ciliary body, an important tissue in
the regulation of IOP. The findings suggest that these endogenous compounds may
have a role in this disease, particularly with respect to regulation of IOP.
DOI: 10.1016/j.bbrc.2005.03.095
PMID: 15823551 [Indexed for MEDLINE]