Expression patterns of nm23 genes during mouse organogenesis
Cell Tissue Res. 2005-08-05; 322(3): 365-378
DOI: 10.1007/s00441-005-0036-9
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1. Cell Tissue Res. 2005 Dec;322(3):365-78. Epub 2005 Aug 5.
Expression patterns of nm23 genes during mouse organogenesis.
Amrein L(1), Barraud P, Daniel JY, Pérel Y, Landry M.
Author information:
(1)EA DRED 483, Laboratoire de Biologie de la Différenciation et du
Développement, Université Victor Ségalen, Bordeaux 2, 33 076, Bordeaux Cedex,
France.
Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family
of genes, may be involved in various cellular differentiation and proliferation
processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and
-M4 during embryonic mouse development. In situ hybridization data has revealed
the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1
and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2
mRNA is found ubiquitously. Irrespective of the developmental state studied,
nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the
cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal
differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating
layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms
are sequentially involved in various developmental processes.
DOI: 10.1007/s00441-005-0036-9
PMID: 16082520 [Indexed for MEDLINE]