Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia

X. Zhang, T. Shi, K. Holmberg, M. Landry, W. Huang, H. Xiao, G. Ju, T. Hokfelt
Proceedings of the National Academy of Sciences. 1997-01-21; 94(2): 729-734
DOI: 10.1073/pnas.94.2.729

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1. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):729-34.

Expression and regulation of the neuropeptide Y Y2 receptor in sensory and
autonomic ganglia.

Zhang X(1), Shi T, Holmberg K, Landry M, Huang W, Xiao H, Ju G, Hökfelt T.

Author information:
(1)Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

The Y2 subtype of neuropeptide tyrosine (NPY) receptors (Y2R) and some
neuropeptides have been studied with in situ hybridization in sensory and
autonomic neurons of rat and monkey. Between 10% and 20% of the lumbar dorsal
root ganglion (DRG) neuron profiles (NPs) contain Y2R mRNA in the rat and monkey.
In rat DRGs Y2R mRNA is expressed in calcitonin gene-related peptide
(CGRP)-positive, medium-sized, and large neurons, that is in a complementary
fashion to the Y1R that is located in small CGRP neurons. In monkey DRGs Y2R mRNA
is expressed mainly in small neurons. Peripheral axotomy up-regulates the Y2R in
small and large DRG neurons in both species. Y2R and NPY mRNAs are colocalized in
many large neurons in axotomized rat DRGs. Y2R mRNA is expressed in 50% of the
NPs in the nodose ganglion with a modest increase after axotomy. Y2R mRNA is
detected in a few NPs in normal rat superior cervical ganglia, with a marked
increase after transection of the carotid nerves. No Y2R mRNA-positive, but many
(approximately 30%) weakly Y1R mRNA-positive NPs were found in the sphenopalatine
ganglion. Finally, Y2R mRNA levels increase in rat spinal motoneurons after
axotomy. Thus, under normal circumstances NPY may act on Y1 and Y2Rs expressed,
respectively, in small and large CGRP-positive DRG neurons in the rat. Y2R may be
an important receptor in the viscero-sensory neurons. Y2Rs may be particularly
important after axotomy serving as presynaptic and/or autoreceptors on rat DRG,
superior cervical ganglion, and nodose ganglion neurons and as presynaptic
receptors in monkey DRG neurons.

DOI: 10.1073/pnas.94.2.729
PMID: 9012853 [Indexed for MEDLINE]

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