Excitatory response of prefrontal cortical fast-spiking interneurons to ventral tegmental area stimulation in vivo
Synapse. 2006-01-01; 59(7): 412-417
DOI: 10.1002/syn.20255
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1. Synapse. 2006 Jun 1;59(7):412-7.
Excitatory response of prefrontal cortical fast-spiking interneurons to ventral
tegmental area stimulation in vivo.
Tseng KY(1), Mallet N, Toreson KL, Le Moine C, Gonon F, O’Donnell P.
Author information:
(1)Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany,
New York 12208, USA.
Prefrontal cortical (PFC) pyramidal neurons (PN) and fast spiking interneurons
(FSI) receive dopaminergic (DA) and non-DA inputs from the ventral tegmental area
(VTA). Although the responses of PN to VTA stimulation and DA administration have
been extensively studied, little is known about the response of FSI to
mesocortical activation. We explored this issue using single and double in vivo
juxtacellular recordings of medial PFC PN and FSI with chemical VTA stimulation.
Electrophysiological characteristics combined with Neurobiotin staining and
parvalbumin immunohistochemistry allowed identification of recorded cells as FSI
or PN. NMDA injection into the VTA increased firing in all FSI tested (n = 7),
whereas most PN (7/11) responded with an inhibition. Furthermore, FSI excitation
matching the temporal course of PN inhibition was observed with FSI-PN paired
recordings (n = 5). These divergent electrophysiological responses to
mesocortical activation could reflect PFC GABAergic interneurons contributing to
silencing PN. Thus, the mesocortical system could provide a critical control of
PFC circuits by simultaneously affecting FSI and PN firing.
Copyright 2006 Wiley-Liss, Inc.
DOI: 10.1002/syn.20255
PMCID: PMC2190627
PMID: 16485264 [Indexed for MEDLINE]